Trametinib - CAS 871700-17-3

Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.

Apoptosis, MEK, Autophagy

Autophagy, Apoptosis, MAPK

871680

0.9996

C26H23FIN5O4

615.39

N(C1=C2C(N(C(=O)N(C2=O)C3CC3)C4=CC(NC(C)=O)=CC=C4)=C(C)C(=O)N1C)C5=C(F)C=C(I)C=C5

-20°C

Ice Packs

Small Compound