TREM2-IN-1 - CAS 2000236-36-0

TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.

Others, Apoptosis

Others, Apoptosis

2000236-36-0

0.9856

C46H68N2O20Pt

1164.12

[O-](C(CCC(O[C@@H]1O[C@]2([C@]34[C@]([C@H]1C)(CC[C@@H](C)[C@@]3(CC[C@](C)(O2)OO4)[H])[H])[H])=O)=O)[Pt+4]56([O-]C(CCC(O[C@@H]7O[C@]8([C@]9%10[C@]([C@H]7C)(CC[C@@H](C)[C@@]9(CC[C@](C)(O8)OO%10)[H])[H])[H])=O)=O)([NH2]C%11C([NH2]5)CCCC%11)[O-]C(=O)C(=O)[O-]6

-20°C

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