Tri-GalNAc (OAc) 3 - CAS 1159408-64-6

Tri-GalNAc (OAc) 3, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome targeting chimeras (LYTAC) . These chimeras exploit the asialoglycoprotein receptor to direct protein degradation targets to the lysosome [1].

LYTACs

PROTAC

1159338

C79H128N10O36

1793.91

O(C(C)=O)[C@@H]1[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]3[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)=O)=O)N)=O)=O)O[C@H](COC(C)=O)[C@@H]1OC(C)=O

-20°C

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PROTAC