Trimetazidine - CAS 5011-34-7

Trimetazidine is a non-haemodynamic antianginal agent that selectively inhibits the mitochondrial enzyme 3-ketoacyl coenzyme A thiolase (LC 3-KAT), thereby preventing β-oxidation of free fatty acids, with an IC50 value of 75 nM. Trimetazidine prevents ischaemia-reperfusion injury by altering cardiac metabolism, exhibiting antioxidant and anti-ischaemic effects.

Others, Mitochondrial Metabolism, Antioxidant, Autophagy

Autophagy, Others, Metabolism, Oxidation-Reduction

4970

0.999

C14H22N2O3

266.34

COc1ccc(CN2CCNCC2)c(OC)c1OC

-20°C

Ice Packs

Small Compound