Trimethylamine N-oxide - CAS 1184-78-7

Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite derived from dietary choline, betaine, and carnitine. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation through the activation of the TGF-β/Smad2 signaling pathway. TMAO is commonly used to induce cardiac fibrosis models.

TGF-beta/Smad, NOD-like Receptor (NLR), Reactive Oxygen Species

Stem Cells, Immunology/Inflammation, NF-κB, Metabolism

1099

0.98

C3H9NO

75.11

C[N+](C)(C)[O-]

-20°C

Ice Packs

Natural Product