Trimethylamine N-oxide dihydrate - CAS 62637-93-8

Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.

Endogenous Metabolite

Metabolism

62536

0.9875

C3H13NO3

111.14

O.O.C[N+](C)(C)[O-]

-20°C

Ice Packs

Natural Product