Triptriolide - CAS 137131-18-1

Triptriolide inhibits puromycin aminonucleoside (PAN) -induced apoptosis in mouse podocytes by modulating Bcl-2 family proteins and suppressing Caspase-3. It also promotes cell survival and protects podocyte function by activating the TAK1-NF-κB signaling pathway and upregulating the podocyte protein podocin.

NF-κB, Apoptosis, MAPK, MAP3K

MAPK, Apoptosis, NF-κB

137131-18-1

C20H26O7

378.416

C[C@@]12[C@@]34[C@@]5([C@@](O5)(C[C@]1(C6=C(CC2)C(=O)OC6)[H])[H])[C@H](O)[C@@]([C@@H](C)C)(O)[C@H](O)[C@@]3(O4)[H]

-20°C

Ice Packs

Natural Product