TRK-IN-23 - CAS 2924344-29-4

TRK-IN-23 (compound 24b) is a potent, orally active TRK inhibitor with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [1].

Apoptosis, Trk receptor

Apoptosis, Tyrosine Kinase/Adaptors

2924311

C20H17FN4O2

364.37

C(=C\1/C=2C(NC1=O)=CC=C(NCC3=C(OC)C=CC(F)=C3)C2)\C4=CN=CN4

-20°C

Ice Packs

Small Compound