TRK-IN-24 - CAS 2937544-01-7

TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with corresponding IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM. It demonstrates antitumor activity in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models and inhibits the proliferation of Ba/F3 cells expressing single mutants SF, GK, and xDFG, with an IC50 range of 1.43-47.56 nM [1].

Trk receptor

Tyrosine Kinase/Adaptors

2937544-01-7

C39H45N7O3

659.82

O=C1C2=NN3C(=CN=C3C=C2)C#CC4=C(C)C(C(NC5=CC(=CC(CN6CCN(C)CC6)=C5)C7CC7)=O)=CC(=C4)OCCCCCCCN1

-20°C

Ice Packs

Small Compound