TRPM7-IN-1 - CAS 1909225-07-5

TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K/Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.

PI3K, Akt, Apoptosis, Antibacterial

Microbiology/Virology, PI3K/Akt/mTOR signaling, Apoptosis, Cytoskeletal Signaling

1909225-07-5

C23H25N5O3

419.48

O=C(NC(=O)C=1C=CC=CC1N(C)C)NC2=CC=C(OC=3N=C(C=C(N3)C)C)C(=C2)C

-20°C

Ice Packs

Small Compound