TRPV1 antagonist 10 - CAS 896584-55-7

TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM) . It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.

OAT, Cytochromes P450, transporter, TRP/TRPV Channel

Membrane transporter/Ion channel, Metabolism

896522

C16H14N2O5

314.293

O=C(NC1=CC=C2OCOC2=C1)NC3=CC=C4OCCOC4=C3

-20°C

Ice Packs

Small Compound