TRPV1-IN-3 - CAS 87657-67-8

TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor utilized in idiopathic pulmonary fibrosis research. It demonstrates antifibrotic activity in vitro (IC50 = 0.51 μM) by inhibiting the TGF-β/Smads and MAPK pathways, thereby affecting the expression of fibrosis markers collagen I and α-SMA. In vivo, TRPV1-IN-3 significantly reduces collagen deposition in lung tissue, improves alveolar structure, and increases survival rates in mice with Bleomycin-induced pulmonary fibrosis.

TRP/TRPV Channel

Membrane transporter/Ion channel

87582

C19H20O3

296.36

C(=C/C(CCCCC1=CC=CC=C1)=O)\C2=CC(O)=C(O)C=C2

-20°C

Ice Packs

Small Compound