TrxR/EGFR-IN-1 - CAS 3038386-42-1

TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.

EGFR, Ferroptosis, Apoptosis

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis, Angiogenesis

3038343

C24H24AuClFN6O2P

710.878

FC1=CC=C(C=C1Cl)NC=2N=CN=C3C=C(OC)C(OCC#[C-][Au+][P]45CN6CN(CN(C6)C4)C5)=CC32

-20°C

Ice Packs

Small Compound