TrxR-IN-8 - CAS 2857180-28-8

TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.

Apoptosis, Reactive Oxygen Species

Metabolism, NF-κB, Apoptosis, Immunology/Inflammation

2857144

C16H16INO2

381.21

[I-].O(C=1C=C(OC)C=2C=3C=CC=CC3C=[N+](C2C1)C)C

-20°C

Ice Packs

Small Compound