TSHR antagonist S37a - CAS 2143452-20-2

TSHR antagonist S37a is a selective, orally bioavailable TSHR (thyroid-stimulating hormone receptor) antagonist that inhibits TSH-induced cyclic adenosine monophosphate (cAMP) in TSHR-expressing HEK 293 cells, suitable for studying Graves' orbitopathy.

TSH Receptor

GPCR/G Protein

2143430

0.9837

C25H20N2O3S2

460.57

O=C1[C@@]2([C@@]3([C@@]4([C@]([C@@](C3)([C@@]2(C(=O)N1C5=CC=CC=C5)[H])[H])(SC6=C([C@H]4C7=CC=CC=C7)SC(=O)N6)[H])[H])[H])[H]

-20°C

Ice Packs

Small Compound