TSI-01 - CAS 704878-75-1

TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 μM and 3.02 μM for human LPCAT2 and LPCAT1, respectively) . At 60 μM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.

Others, PAFR

Others, GPCR/G Protein

704802

0.9987

C14H11Cl2NO4

328.15

O=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O

-20°C

Ice Packs

Small Compound