Tubulin-IN-51 - CAS 849550-36-3

Tubulin-IN-51 is an orally active tubulin inhibitor with an IC50 of 31 nM. It promotes tubulin polymerization in vitro and does not competitively bind with Paclitaxel. Tubulin-IN-51 inhibits the binding of Vinblastine to tubulin and suppresses tumor growth in various nude mouse xenograft models, including those using A549 human non-small cell lung cancer (NSCLC) cells and U87-MG human glioblastoma.

Apoptosis, Microtubule Associated

Apoptosis, Cytoskeletal Signaling

849511

C18H18ClF5N6O

464.82

N([C@@H](C(F)(F)F)C)C1=C(C(Cl)=NC=2N1N=CN2)C3=C(F)C=C(OCCCNC)C=C3F

-20°C

Ice Packs

Small Compound