Tubulin polymerization-IN-68 - CAS 2924156-96-5

Tubulin polymerization-IN-68 (compound 32) serves as a tubulin inhibitor, disrupting cellular microtubule networks by hindering tubulin polymerization. It also upregulates PARP-1 and caspase-3 expression, thereby inducing apoptosis and exhibiting anticancer properties. Notably, Tubulin polymerization-IN-68 effectively suppresses HepG2 cells with an IC50 of 93 nM and markedly reduces the growth of HepG2 xenograft tumors in nude mice through oral administration.

Caspase, PARP, Apoptosis, Microtubule Associated

Proteases/Proteasome, Apoptosis, Chromatin/Epigenetic, Cytoskeletal Signaling, DNA Damage/DNA Repair

2924055

C16H13N3O

263.29

O=C1NC(NC=2C=CC=CC12)C=3C=CC=4NC=CC4C3

-20°C

Ice Packs

Small Compound