Tubulin polymerization-IN-77 - CAS 3023350-32-2

Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.

Microtubule Associated

Cytoskeletal Signaling

3023316

C22H19BrF3NO7

546.288

O(C)C=1C=2[C@@](N(C(F)(F)F)CCC2C(Br)=C3C1OCO3)([C@@]4(C=5C(C(=O)O4)=C(OC)C(OC)=CC5)[H])[H]

-20°C

Ice Packs

Small Compound