Tumour-associated MUC1 epitope - CAS 129437-45-2

Tumor-associated MUC1 epitope, a biologically active peptide, is the distinctive feature of MUC1 mucin—a significantly glycosylated type I transmembrane glycoprotein. Its extracellular domain comprises variable numbers of tandem repeats (VNTR) of a 20 amino acid sequence. This peptide is overexpressed on the surface of various human adenocarcinomas and hematological malignancies like multiple myeloma and B-cell lymphoma, rendering MUC1 a widely relevant target for immunotherapeutic approaches.

129437-45-2

C80H127N25O28

1887.02

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC(CNC(=O)[C@H]2N(C([C@@H](NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@H]4CCCN4)CC(O)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC3)C)=O)CCC2)=O)CO)=O)[C@@H](C)O)=O)C)=O)CCC1)N5[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CO)=O)[C@@H](C)O)=O)[C@@H](C)C)=O)=O)=O)C)=O)CCC5

-20°C

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