TUS-007 - CAS 2227029-18-5

TUS-007, a modified CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) molecule originally derived from a proteasome inhibitor, scarcely affects proteasome activity. It is a potent, orally active degrader of KRAS G12D/V, effective in cell-free chemical knockdown of KRAS G12D/V. Furthermore, TUS-007 has been shown to suppress tumor growth [1].

Others, Kras, Ras

Others, MAPK

2227006

C44H54Cl2N8O5

845.86

CC[C@@H](C)[C@H](NC(=O)CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)C(=O)Nc1ccc2nc(Cc3c[nH]c4ccccc34)[nH]c2c1

-20°C

Ice Packs

Small Compound