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Molfinity

Tuvusertib - CAS 1613200-51-3

Tuvusertib - CAS 1613200-51-3

MF-0004507-01

$51.86 USD
$51.86 USD
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Product Details

  • Bioactivity

    Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.

  • Target

    ATM/ATR, Chk, Apoptosis

  • Related Pathways

    DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Apoptosis, Cell Cycle/Checkpoint

  • CAS Number

    1613146

  • Purity

    0.9966

  • Molecular Formula

    C16H12F2N8O

  • Molecular Weight

    370.32

  • SMILES

    Cn1cncc1-c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound