Tuxobertinib - CAS 2414572-47-5

Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, with KDs of 0.2, 0.76, 13, and 1.2 nM for EGFR, HER2, BLK, and RIPK2, respectively, and exhibits anticancer activity.

RIP kinase, HER, EGFR, BTK

NF-κB, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis, Angiogenesis

2414520

0.9922

C29H29ClN6O4

561.03

Clc1cc(Nc2ncnc3cc(OCCN4CCOCC4)c(NC(=O)C=C)cc23)ccc1OCc1ccccn1

-20°C

Ice Packs

Small Compound