TWIK-1/TREK-1-IN-1 - CAS 1440532-30-8

Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of 9.36 μM for TREK-1 homodimers and 14.6 μM for TWIK-1/TREK-1 heterodimers, demonstrating antidepressant-like effects [1].

Potassium Channel

Membrane transporter/Ion channel

1440494

C21H24F3NO3

395.42

OC1(CCN(C[C@H](COC2=CC=C(C(F)(F)F)C=C2)O)CC1)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound