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Molfinity

TX1-85-1 - CAS 1603845-32-4

TX1-85-1 - CAS 1603845-32-4

MF-0034271-01

$57.84 USD
$57.84 USD
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Product Details

  • Bioactivity

    TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM) . TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.

  • Target

    EGFR

  • Related Pathways

    Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling

  • CAS Number

    1603809

  • Purity

    0.9812

  • Molecular Formula

    C32H36N8O3

  • Molecular Weight

    580.68

  • SMILES

    CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound