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Molfinity

Tyk2-IN-22 - CAS 933667-23-3

Tyk2-IN-22 - CAS 933667-23-3

MF-0112435-01

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Product Details

  • Bioactivity

    Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.

  • Target

    JAK

  • Related Pathways

    Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells, JAK/STAT signaling, Chromatin/Epigenetic

  • CAS Number

    933641

  • Molecular Formula

    C16H16ClN5O2

  • Molecular Weight

    345.78

  • SMILES

    O=C1C=C(N=C2NC(=NN12)C=3C=CC(Cl)=CC3)CN4CCOCC4

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound