TYM-3-98 - CAS 2820244-59-3

TYM-3-98 is a selective inhibitor of PI3Kδ with an IC50 of 7.1 nM. It inhibits the proliferation of B lymphoma cells by inducing apoptosis and suppressing the PI3K/AKT/mTOR signaling pathway. In mouse/rat models, TYM-3-98 displays favorable pharmacokinetic properties and antitumor activity without significant toxicity.

PI3K, Apoptosis

Apoptosis, PI3K/Akt/mTOR signaling

2820182

C28H23ClFN7O3S

592.05

O=S(=O)(C=1C=CC=C(C1)N2N=C(C=3C=CC(Cl)=CC32)C(N4N=C(C=5C=CC(OC)=C(F)C5)C=6C(=NC=NC64)N)C)C

-20°C

Ice Packs

Small Compound