Type II topoisomerase inhibitor 1 - CAS 2245691-60-3

Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with an IC50 value of 1.7 nM and forms hydrogen bonds with the Asp73 residue. It inhibits topoisomerase IV activity with an IC50 value of 0.98 μM and is applicable in the antibacterial area [1] [2].

Topoisomerase, Antibacterial, Others, DNA/RNA Synthesis

Microbiology/Virology, Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair

2245628

C18H15N3O4

337.33

N(C)C1=C2C(C=C(C(NC3=CC=C(C(O)=O)C=C3)=O)C(=O)N2)=CC=C1

-20°C

Ice Packs

Small Compound