Tyrphostin 8 - CAS 3785-90-8

Tyrphostin 8 (4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect.

Phosphatase, GTPase, Ras, EGFR

GPCR/G Protein, MAPK, JAK/STAT signaling, Metabolism, Tyrosine Kinase/Adaptors, Angiogenesis

3687

0.9986

C10H6N2O

170.17

OC1=CC=C(C=C(C#N)C#N)C=C1

-20°C

Ice Packs

Small Compound