U-51605 - CAS 64192-56-9

U-51605, a stable analog of the endoperoxide prostaglandin H2 (PGH2), functions as an inhibitor with greater selectivity towards prostacyclin (PGI) synthase over thromboxane (TX) synthase. It also acts as a partial agonist at TP receptors. Studies show that at a concentration of 2.8 μM, U-51605 effectively inhibits PGI synthase in human foreskin fibroblasts, while a concentration of 5.6 μM is required to inhibit human platelet TX synthase. Furthermore, U-51605, at up to 1 μM, decreases the release of prostacyclin in SHR aorta triggered by the calcium ionophore A-23187 without impacting TXA2 production, and notably enhances the release of PGE2 and PGF2α.

PGE Synthase, Others

Immunology/Inflammation, Others

64192-56-9

C20H32N2O2

332.488

CCCCCC\C=C\[C@@H]1C(CC=CCCCC(O)=O)C2CC1N=N2

-20°C

Ice Packs

Small Compound