UCK2 Inhibitor-3 - CAS 2376687-49-7

UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively.

DNA/RNA Synthesis, Others

Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair

2376631

C19H13BrFN5O2S

474.31

O=C1N=C(N=C2C1=CNN2C3=CC=C(F)C=C3)SCC(=O)NC4=CC=C(Br)C=C4

-20°C

Ice Packs

Small Compound