UK-122 TFA salt - CAS 1186653-73-5

UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM) . The IC (50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC (50) > 100 micromol/L) but significantly inhibited the migration and invasion of this pancreatic cancer cell line.

Others, PAI-1

Others, Metabolism

1186575

C19H14F3N3O4

405.33

C(C(O)=O)(F)(F)F.C(=C\1/N=C(OC1=O)C2=CC=CC=C2)\C3=CC=C(C(=N)N)C=C3

-20°C

Ice Packs

Small Compound