Umbralisib tosylate - CAS 1532533-72-4

Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) . This compound is utilized in the research of hematological malignancies.

Casein Kinase, Others, PI3K

Stem Cells, Others, PI3K/Akt/mTOR signaling, Metabolism

1532457

C38H32F3N5O6S

743.75

S(=O)(=O)(O)C1=CC=C(C)C=C1.NC1=C2C(=NN([C@@H](C)C3=C(C(=O)C=4C(O3)=CC=C(F)C4)C5=CC(F)=CC=C5)C2=NC=N1)C6=CC(F)=C(OC(C)C)C=C6

-20°C

Ice Packs

Small Compound