UNC2170 maleate - CAS 2173992-60-2

53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.

Others, DNA/RNA Synthesis

Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2173992-60-2

C14H21BrN2O?C4H4O4

429.31

C(=CC(O)=O)C(O)=O.C(NCCCNC(C)(C)C)(=O)C1=CC(Br)=CC=C1

-20°C

Ice Packs

Small Compound