UNC3474 - CAS 1648707-79-2

UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 μM. It impedes 53BP1's recruitment to DNA double-strand breaks (DSBs), maintaining the protein's autoinhibited state within cells [1].

Others, MDM-2/p53

Apoptosis, Others

1648707-79-2

C17H28N2O

276.42

O=C(NCCCNC(C)(C)C)C1=CC=CC(=C1)C(C)C

-20°C

Ice Packs

Small Compound