UNC5293 - CAS 2226789-82-6

UNC5293 is a potent, orally available and highly MERTK-selective inhibitor with Ki of 190 pM. UNC5293 inhibits MERTK (IC 50 =0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research [1].

Others, FLT, ALK, TAM Receptor

Others, Angiogenesis, Tyrosine Kinase/Adaptors

2226701

C30H42N6O2

518.69

CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1

-20°C

Ice Packs

Small Compound