UNC8153 - CAS 2929304-60-7

UNC8153 is a selective degrader of the nuclear receptor binding SET domain-containing 2 (NSD2), with a binding Kd of 24 nM. It effectively reduces NSD2 protein levels and the dimethylation of lysine 36 on histone 3 (H3K36me2) chromatin. Its simple warhead promotes proteasome-dependent degradation of NSD2 through a novel mechanism.

Histone Methyltransferase

Chromatin/Epigenetic

2929304-60-7

C33H37N5O5

583.68

O=C(NC1=CC=C(C=C1)C(=O)NCCCCCCN)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5

-20°C

Ice Packs

Small Compound