Uncarinic acid E - CAS 277751-61-8

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p- (E) -coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml.

Caspase, Bcl-2 Family, Antifection, MEK, PI3K, p53

PI3K/Akt/mTOR signaling, Microbiology/Virology, MAPK, Proteases/Proteasome, Apoptosis

277682

C39H54O6

618.84

CC1(C)CC[C@@]2(CC[C@]3(COC(=O)\C=C\c4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O

-20°C

Ice Packs

Natural Product