UNI418 - CAS 1802068-51-4

UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM) . It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM) . Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM) .

SARS-CoV, PI3K

Microbiology/Virology, PI3K/Akt/mTOR signaling

1802013

C22H16N6

364.4

N=1C=CC(=CC1)C2=NC3=CC=CC=C3C(=N2)NC4=NNC(=C4)C=5C=CC=CC5

-20°C

Ice Packs

Small Compound