Upacicalcet - CAS 1333218-50-0

Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.

Calcium Channel, CaSR

GPCR/G Protein, Metabolism, Membrane transporter/Ion channel

1333168

0.9988

C11H14ClN3O6S

351.76

N(C(NC[C@@H](C(O)=O)N)=O)C1=CC(S(=O)(=O)O)=CC(Cl)=C1C

-20°C

Ice Packs

Small Compound