UR-7247 - CAS 177847-28-8

UR-7247 is a novel orally active angiotensin II subtype I (AT1) antagonist, demonstrating very long pharmacological effects. in vivo studies indicate no significant difference between 10 mg UR-7247 and 100 mg losartan four hours post-administration, while in vitro blockade with 100 mg losartan exceeds that observed with UR-7247, confirming UR-7247’s extended plasma half-life potentially due to high-affinity protein binding, highlighting its long-lasting, well-tolerated AT1 receptor antagonism in healthy subjects.

RAAS

Endocrinology/Hormones

177811

1

C24H26N6O2

430.5

O=C(O)C=1C(=NN(C1CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCC)C(C)C

-20°C

Ice Packs

Small Compound