UR778Br - CAS 866127-80-2

UR778Br targets the GTPase-activating protein-related domain (GRD domain) of the IQGAP1 protein. This compound inhibits the proliferation of human acute myeloid leukemia (AML) by arresting the cell cycle during the G2/M phase and inducing apoptosis (cell death) . UR778Br suppresses colony formation in primary cells and AML cells without significant effects on normal bone marrow cells.

Apoptosis

Apoptosis

866127-80-2

C20H20BrNO4

418.28

O=C(C=1C=CC=CC1O)CC2(O)C(=O)N(C3=CC=C(Br)C=C32)CCCC

-20°C

Ice Packs

Small Compound