URAT1&XO inhibitor 2 - CAS 1239488-96-0

Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].

Xanthine Oxidase, OAT

Membrane transporter/Ion channel, Metabolism

1239392

C14H12BrNO3

322.15

C(\CC1=CC=C(Br)C=C1)(=N\O)/C2=C(O)C=C(O)C=C2

-20°C

Ice Packs

Small Compound