URMC-099 - CAS 1229582-33-5

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM) .

Syk, Src, Trk receptor, IGF-1R, Bcr-Abl, CDK, SGK, ROCK, VEGFR, DNA Alkylation, MLK, LRRK2, Aurora Kinase, c-Met/HGFR, MEK, Autophagy

Stem Cells, DNA Damage/DNA Repair, Metabolism, Autophagy, Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, MAPK, Cell Cycle/Checkpoint

1229544

0.9998

C27H27N5

421.54

CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1

-20°C

Ice Packs

Small Compound