USP28-IN-2 - CAS 2931509-11-2

USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 μM), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].

Others, DUB

Others, Ubiquitination, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

2931496

C23H20Cl2N2O3S

475.39

-20°C

Ice Packs

Small Compound