USP7-IN-4 - CAS 2196243-57-7

USP7-IN-4 (USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4;11 (acute lymphoblastic leukemia cell line) .

MDM-2/p53, DUB, p53

Apoptosis, DNA Damage/DNA Repair, Ubiquitination, Cell Cycle/Checkpoint

2196179

>99.99%

C29H34N6O3

514.62

CN1C(=C2C(C(=O)N(CC3(O)CCN(C(C[C@@H](C)C4=CC=CC=C4)=O)CC3)C=N2)=N1)C5=CC=C(CN)C=C5

-20°C

Ice Packs

Small Compound