USP8-IN-3 - CAS 2477651-10-6

USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D. USP8-IN-3 inhibited the proliferation of GH3 and H1957 cells with GI50 values of 37.03 μM and 6.01 μM, respectively. USP8-IN-3 is a potential compound for the treatment of cancer and viral infections.

DUB

Ubiquitination, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2477635

0.9979

C18H18F3N5O2S

425.43

C(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=CC=C(N(=O)=O)C=C3)=S)CC2

-20°C

Ice Packs

Small Compound