αvβ1 integrin-IN-2 - CAS 2234874-68-9

αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. This compound also inhibits other integrins with IC50 values of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), and 87 nM (ανβ8), as determined by the SPRA assay [1].

Integrin

Cytoskeletal Signaling

2234797

C29H38N4O4

506.64

C(CC=1C=C(OCCC=2NC=3C(=CC2)CCCN3)N(C)N1)(CC(O)=O)C4=C(OC)C=CC(C(C)(C)C)=C4

-20°C

Ice Packs

Small Compound