V-9302 hydrochloride - CAS 2416138-42-4

V-9302 hydrochloride is a competitive transmembrane glutamine flux antagonist that selectively targets the amino acid transporter ASCT2/SLC1A5. V-9302 hydrochloride impedes glutamine uptake mediated by ASCT2 (IC50=9.6 μM), inhibits the mTOR signalling pathway, increases oxidative stress and ROS levels, induces autophagy, and exerts antitumour effects.

MTOR, ASCT, Autophagy, ROS

Membrane transporter/Ion channel, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Autophagy

2416138-42-4

0.9731

C34H39ClN2O4

575.14

C(N(CC1=C(OCC2=CC(C)=CC=C2)C=CC=C1)CC[C@@H](C(O)=O)N)C3=C(OCC4=CC(C)=CC=C4)C=CC=C3.Cl

-20°C

Ice Packs

Small Compound