Vactosertib Hydrochloride - CAS 1352610-25-3

Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an orally active and highly efficient ATP-competitive ALK5 (activin receptor-like kinase 5) inhibitor, a TGF-β receptor I inhibitor with anti-metastatic and anticancer properties. It sensitizes pancreatic cancer cells to gemcitabine by inhibiting their viability.

ALK, TGF-beta/Smad

Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors

1352582

0.9803

C22H19ClFN7

435.89

Cl.FC=1C=CC=CC1NCC2=NC(C3=NC(=CC=C3)C)=C(N2)C=4C=CC5=NC=NN5C4

-20°C

Ice Packs

Small Compound